Abstract
BackgroundBronchiectasis (BE) is a chronic structural lung disease with frequent exacerbations, some of which require hospital admission though no clear associated factors have been identified. We aimed to evaluate factors associated with hospitalization due to exacerbations during a 1-year follow-up period.MethodsA prospective observational study was performed in patients recruited from specialized BE clinics. We considered all exacerbations diagnosed and treated with antibiotics during a follow-up period of 1 year. The protocol recorded baseline variables, usual treatments, Bronchiectasis Severity Index (BSI) and FACED scores, comorbid conditions and prior hospitalizations.ResultsTwo hundred and 65 patients were recruited, of whom 162 required hospital admission during the follow-up period. Independent risk factors for hospital admission were age, previous hospitalization due to BE, use of proton pump inhibitors, heart failure, FACED and BSI, whereas pneumococcal vaccination was a protective factor. The area under the receiver operator characteristic curve (AUC) was 0.799 for BSI model was 0.799, and 0.813 for FACED model.ConclusionsPrevious hospitalization, use of proton pump inhibitors, heart failure along with BSI or FACED scores is associated factors for developing exacerbations that require hospitalization. Pneumococcal vaccination was protective. This information may be useful for the design of preventive strategies and more intensive follow-up plans.
Highlights
Bronchiectasis (BE) is a chronic structural lung disease with frequent exacerbations, some of which require hospital admission though no clear associated factors have been identified
Bronchiectasis (BE) is a chronic structural respiratory disease characterized by dilated bronchi that courses with exacerbations that may require hospital admission [1, 2]
Exacerbations may lead to deterioration of lung function, [5] poor prognosis [6] and increased mortality [4, 7] and costs, [8] as in patients with other chronic respiratory diseases [9, 10]
Summary
Bronchiectasis (BE) is a chronic structural lung disease with frequent exacerbations, some of which require hospital admission though no clear associated factors have been identified. Bronchiectasis (BE) is a chronic structural respiratory disease characterized by dilated bronchi that courses with exacerbations that may require hospital admission [1, 2]. The average rate of exacerbations per year varies widely among patients and the causes remain unknown. Exacerbations may lead to deterioration of lung function, [5] poor prognosis [6] and increased mortality [4, 7] and costs, [8] as in patients with other chronic respiratory diseases [9, 10]. Patients with advanced phases of disease and high Bronchiectasis Severity Index (BSI) or FACED scores have an average of two or more exacerbations per year [11], and the trend towards longer hospital stays [4, 12]
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