Factors associated with deep infiltrating endometriosis versus ovarian endometrioma in China: a subgroup analysis from the FEELING study

Yi Dai,Charles Chapron,Xinmei Zhang,Yingfang Zhou,Jinhua Leng,Min Xue,Pengran Sun

doi:10.1186/s12905-018-0697-7

Abstract

BackgroundTo compare potential factors associated with deep infiltrating endometriosis (DIE) versus ovarian endometrioma (OMA) among endometriosis patients in China.MethodsA subgroup analysis of factors associated with DIE versus OMA was performed in Chinese women from the FEELING study. This study included 156 OMA patients and 78 DIE patients. Retrospective information on symptoms and previous medical history was collected via face-to-face interviews; patients also completed a questionnaire to provide information on current habits. Univariate and multivariate logistic regression analyses were conducted to identify potential factors that are associated with DIE versus OMA.ResultsFrom univariate analysis, women who were married, at older age, had any siblings, prior pregnancy, or longer time since age at menarche on the day of visit were more likely to be diagnosed with DIE (P < 0.05). Also, the incidence of previous uterine surgery, menstrual and ovulatory disorders, deep dyspareunia, and gastrointestinal symptoms during menstruation were major factors that were significantly associated with the diagnosis of DIE (P < 0.05). Multivariate analysis showed that women with any siblings, gastrointestinal symptoms during menstruation, or eating a greater number of fruit/vegetables per day were more likely to be diagnosed with DIE. Meanwhile, eating organic food and experiencing stress were major factors that are associated with the diagnosis of OMA.ConclusionsThe findings provide additional information on the potential risk factors that are associated with DIE, compared with OMA among Chinese endometriosis patients. The results may help to better understand DIE versus OMA, and aid in earlier risk stratification and diagnosis of the patients.Trial registrationNCT01351051. Registered 10 May 2011.

Highlights

To compare potential factors associated with deep infiltrating endometriosis (DIE) versus ovarian endometrioma (OMA) among endometriosis patients in China
Data from 78 DIE and 156 OMA Chinese patients were obtained from the FEELING study
Our results showed that women with any siblings, gastrointestinal symptoms during menstruation, and eating a greater number of fruit/ vegetables were more likely to be diagnosed with DIE in the multivariate analysis

Summary

Introduction

To compare potential factors associated with deep infiltrating endometriosis (DIE) versus ovarian endometrioma (OMA) among endometriosis patients in China. Endometriosis, known as ectopic growth of endometrium, is an enigmatic disease that has been consistently associated with dysmenorrhoea, deep dyspareunia, cyclical premenstrual symptoms, and even infertility [1,2,3,4,5,6,7]. It affected 10.8 million people worldwide according to the Global Burden of Disease Study in 2015 [8]. DIE is consistently known to be strongly associated with severe pain, poor quality of life and sexual dysfunction [26, 27] It has long been established as the most aggressive form of the disease [28]. It may be helpful to better understand the pathogenesis of the disease, to develop curative and even preventive treatments that are not available

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Conclusion