Factors associated with carotid intima-media thickness progression in patients with asymptomatic hyperuricemia: insights from the PRIZE study

Yuichi Saito ,Yasuko K Bando ,Sandeep Shakya ,Chikara Ueyama ,Teruo Inoue ,Ryo Hayashida ,Kaoru Takegami ,Hiromi Ueno ,Yohei Yamauchi ,Yosuke Tatami ,Wataru Shimizu ,Masanori Fujimoto ,Nozomu Oda ,Masaharu Ishihara ,Koichi Sohmiya ,Akifumi Kushiyama ,Toshiaki Ban ,Hirotaka Watada ,Tomonobu Takikawa ,Shinichiro Ueda ,Michio Shimabukuro ,Shinichi Niwano ,Satoki Fukae ,Youhei Inoue ,Daigo Mine ,Ai Tamura ,Kazuomi Kario ,Tomomi Matsuura ,Takahisa Shibata ,Takeshi Soeki ,Takashi Kobayashi ,Yoshiaki Kubota ,Kazuki Shiina ,Tomohiko Yoshida,Eri Komai ,Ayumu Yajima ,Hidekazu Nagano ,Masato Watarai ,Akihiro Honda ,Tomoko Ishizu ,Takafumi Mayama ,Yuichi Akasaki ,Hiroyuki Daida ,Y Kawamura ,Munehide Matsuhisa ,Hiroki Kojima ,Sachiko Yamauchi ,Koichi Node ,Yoshifumi Awaji ,Takashi Tsubouchi ,Hirofumi Arai ,Tomohiro Fujisaka ,Rie Ueno ,Kenya Kusunose ,Shuichi Hamasaki ,Shinya Suzuki ,Fumio Terasaki ,Yoshihiro Fukumoto ,Yoshio Kobayashi ,Toyoaki Murohara ,Yosuke Saka ,Tomoyuki Tobushi ,Tomoaki Tanaka ,Hisashi Koide ,Akina Shiga ,Hiroyuki Suzuki ,Hirohisa Amano ,Masahisa Shimpo ,Masatoshi Miyamura ,Ikuko Nakamura ,Mieko Fukui ,Ryo Nakamura ,Hitoshi Nakashima ,Takanori Kuroyanagi ,Nenad Ban ,Masaaki Hoshiga ,Kensaku Shibata ,Ryo Morimoto ,Hideaki Morita ,Sadako Takahashi ,Satoshi Kodera ,Seiji Koga ,Isao Nishi ,Mitsumasa Hata ,Seiko Tokoi ,Yutaka Aoyama ,Kazuo Matsunaga ,Katsunori Nakamura ,Yoshisato Shibata ,Akinori Fujikake ,Daiju Fukuda ,Junya Ako,Michishige Ozeki ,Mitsuru Ohishi ,Yoshihiko Sakai ,Takashi Ishimatsu ,Hisakuni Sekino ,Tetsuya Takiguchi ,Shingo Kono ,Shio Oguchi ,Ichiro Sakuma ,Ayumi Ito ,Yumi Ikehara ,Akira Higashi ,Fumitake Ozaki ,Akio Kuroda ,Kyohei Yamamoto ,Yusuke Ohya ,Nobuhiro Tahara ,Masataka Sata ,Jun Tanigawa ,Soichiro Kashihara ,Goro Yoshioka ,Hajime Kamiya ,Mamoru Nanasato ,Yuji Koide ,Masaaki Okutsu ,Mitsutoshi Oguri ,Shuichi Fujita ,Hiroyuki Tanaka ,Sachiyo Igata ,Tatsuya Maruhashi ,Hiroshi Koiwaya ,Hidemitsu Nakagawa ,Machiko Asaka ,Kazushi Sakane ,Tomoya Hara ,Yusuke Ishiyama ,Shunsuke Eguchi ,Toshimitsu Komatsu ,Takashi Terano ,Tomoko Saisu ,Kotaro Yokote ,Shigekazu Higuchi ,Haruhiko Yoshida ,Tomohiro Ueda ,Iichiro Shimomura ,Hideki Ishii ,Kazutaka Aonuma ,Kazuo Kitagawa ,Koji Maemura ,Yuhei Goriki ,Isao Yaguchi ,Akihito Tanaka ,Tetsuya Watanabe ,Hiroshi Hasegawa ,Satoshi Hoshide ,Yuka Senoo ,Jiko Yamada ,Yusaku Shimbo ,Hiroaki Sano ,Bonpei Takase ,Kuniya Asai ,Yuichi Fujii ,Tetsuya Ishikawa ,Arihide Okahara ,Atsushi Tanaka ,Shiro Hata ,Daigaku Uchida ,Takahide Ito ,Jun‐Ichi Oyama ,Tetsuzo Wakatsuki ,Hiroko Ishigami ,Makoto Saitoh ,Naoto Yokota ,Daisuke Tanimura ,Makoto Suzuki ,Junko Hotchi ,Mami Enomoto ,Kazuhito Hashimoto ,Sadahiro Nomura ,Tazu Tahara ,Toshiaki Kadokami ,Mikiko Kagiyama

doi:10.1038/s41598-023-37183-0

Abstract

Hyperuricemia is reportedly associated with the progression of carotid intima-media thickness (IMT), a surrogate of cardiovascular risks and events. However, factors associated with carotid IMT progression in patients with asymptomatic hyperuricemia are largely unknown. In this post-hoc analysis of the multicenter, randomized PRIZE study, we analyzed data from a total of 326 patients who underwent carotid ultrasonography in a blind manner at baseline and 24 months to evaluate carotid IMT. Mean and maximum IMT at the common carotid artery (CCA) were measured at a central core laboratory. Factors related to the absolute change in mean and maximum IMT from baseline to 24 months were explored. Overall, the adjusted mean [0.0032 (− 0.0214 to 0.0278) mm] and maximum [0.0011 (− 0.0327 to 0.0351) mm] CCA-IMT increased numerically from baseline to 24 months. Multivariable analysis identified higher body mass index, history of atherosclerotic cardiovascular disease (ASCVD), and lower mean CCA-IMT at baseline as significant factors associated with the increase in mean CCA-IMT. In addition, older age and lower mean CCA-IMT at baseline were significant factors for an increased absolute change in the maximum CCA-IMT at 24 months. The present sub-analysis of the PRIZE study showed higher body mass index, history of ASCVD, and older age as significant factors associated with CCA-IMT progression in patients with asymptomatic hyperuricemia. These factors may be considered when identifying the possible risk of atherosclerotic progression in this specific patient population of hyperuricemia.Trial registration: UMIN000012911 and UMIN000041322.

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