Abstract
10 Background: The MDPH, in collaboration with Oak Ridge National Laboratory, under contract with NCI, matched the MA AIDS and Cancer Case Registries in the fall of 1997. AIDS cases diagnosed from 1979-1997 were matched to cancer cases reported from 1982-1995. One goal of this match and data analysis was to determine factors associated with the development of AIDS-defining cancers in diagnosed AIDS cases. Methods: AIDS cases with KS (AIDS/KS) and AIDS cases with AIDS-defining lymphoma (AIDS/LYM) were each compared to all other AIDS cases by clinical and sociodemographic factors. Univariate (chi-square) and multivariate (multiple logistic regression) analyses were performed to determine statistical associations. Results: 1291 persons were reported with AIDS/KS, 427 with AIDS/LYM, 11,236 with AIDS and no KS, and 12,100 with AIDS and no AIDS-defining lymphoma. Gender, race/ethnicity, mode of AIDS transmission, year of AIDS diagnosis, vital status and opportunistic infection (OI) at AIDS diagnosis were all significantly associated (p <0.05) with having AIDS/KS (versus no KS) and AIDS/LYM (versus no lymphoma) in the univariate analysis. Age group was only associated with AIDS/KS. Adjusted analysis showed that the AIDS/KS group was more likely to be: men who have sex with men, 30-39 years old, white, diagnosed before 1993, dead, and diagnosed with both an AIDS-defining lymphoma and KS. The AIDS/LYM group was less likely to be black or injection drug user; and more likely to have AIDS diagnosed after 1992, be initially diagnosed with an OI, and be dead. The AIDS/LYM group also was more likely to be diagnosed with both KS and an AIDS-defining lymphoma. There was no association with gender or age. Conclusions: Variables associated with AIDS/LYM are different from those associated with AIDS/KS. Findings may represent biological differences, differences in rates of disease detection, and the effect of people living longer with HIV infection. TableADJUSTED ANALYSIS OF AIDS-DEFINING LYMPHOMA.
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