Factors Associated With Acute Exacerbation in COPD Patients With Mild-to-Moderate Airflow Limitation

Abstract

SESSION TITLE: COPD Posters III SESSION TYPE: Original Investigation Poster PRESENTED ON: Wednesday, October 28, 2015 at 01:30 PM - 02:30 PM PURPOSE: The aim of this study was to compare the clinical characteristics of patients with mild-to-moderate airflow limitation according to the experience the acute exacerbation. METHODS: The patients included in the present study were from the Korean COPD Subtype Study (KOCOSS) cohort. The patients were recruited from 37 referral hospitals in Korea. The definition of COPD was adopted by the GOLD guideline. We obtained the clinical data from the medical record and compared the clinical, spirometric data according to the development of exacerbation during the follow-up period RESULTS: A total of 570 patients with mild-to-moderate airflow limitation were enrolled. A total of 9.3% had FEV1>80% of predicted value. The mean CAT score was 13.9 ± 6.9. The mean SGRQ-c was 30.4 ± 6.5. There were 114 patients (20%) who had experienced one year before enrollment. A total of 17.4% and 14.2% of patients had history of measles and pneumonia, respectively. When adopting 2011 GOLD classification, 24.9% and 74.7% of the patients were classified as GOLD A and B, respectively. During the first 2 years of follow-up period, 17.5% of patients experienced acute exacerbation. SGRQ-c and CAT score were significantly higher in patients with exacerbation than patients without exacerbation (36.3 ± 2.0 vs. 25.6±1.5, 16.6±79 vs. 12.1±6.0, respectively). Patient with exacerbation had allergic rhinitis, hyperlipidemia more frequently, which is statistically significant. A total of 83.3% of patients with history of exacerbation at enrollment experienced exacerbation during the follow-up period. A total 22.0% and 24.1% of the patients with exacerbation had history of pneumonia and measles, which is higher than that of patients without exacerbation (p=0.014 and 0.044, respectively). CONCLUSIONS: A total of 17.5% of mild to moderate COPD patients experienced acute exacerbation during 2 years of follow up. Development of acute exacerbations is associated with poor quality of life, hyperlipidemia, allergic rhinitis, history of acute exacerbation, history of pneumonia and history of measles CLINICAL IMPLICATIONS: A subsequent number of patients with mild-to-moderate airflow limitation experienced exacerbations. Presence of co-morbidities, quality of life and past medical history should be assessed meticulously in order to differentiate patients with high risk of exacerbation. DISCLOSURE: The following authors have nothing to disclose: Yong Il Hwang, Chang Youl Lee, Sunghoon Park, Joo Hee Kim, Yong Bum Park, Seung Hun Jang, Kwang Ha Yoo, Chin Kook Rhee, Hyoung Kyu Yoon, Ki-Suck Jung No Product/Research Disclosure Information