Factors Associated with Achieving Hematological Response in CML (Chronic Myeloid Leukemia) Patient

Abstract

Background: The goal of CML therapy is to achieve complete hematological response first, then cytogeneticresponse andcomplete molecular response at the very end. Achieving a complete hematological responseis the easiest and relatively inexpensive to detect. Several factors are thought to have an association withachieving hematological response. This study sought to determine the factors associated with achievinghematological response in CML patientsMethod: We conducted an observational retrospective cohort study of CML patients at Wahidin SudirohusodoHospital and its network on 2018-2019 period. Diagnosis was done by positive BMP (Bone Marrow Punctie)results for CML, then a monthly blood check until a hematological response was achieved.Results: There wer 39 research subjects, 19 male (48.7%) and 20 female (51.3%). No association foundbetween age, gender and achievement of hematological response. Type of therapy was significantlycorrelated with the achievement of hematological response, with the highest number found in Nilotinibtherapy compared to other group. (54,1%; p = 0.046) Subjects who achieve hematological response had alower percentage of blast cells. (6.1% vs. 7.9% ; p = 0.016)Conclusion: The use of Nilotinib therapy was significantly associated with a succesful achievementof hematological response. A lower percentage of blast cells was found in CML patients who achievedhematological response.