Factors Affecting Uric Acid Changes in Pulmonary Tuberculosis Patients Who Received Oral Anti Tuberculosis Therapy During One Month

Abstract

Background: Pyazinamide (PZA) and Ethambutol (ETB) are tuberculosis drugs that can increase uric acidlevels by decreasing excretion and increasing uric acid reabsorption. Increased levels of uric acid can causearthritis, arthralgia and gout.Objective: To evaluate the association of uric acid levels with age, sex and body mass index (BMI) andarthralgia incidence.Method: The study was conducted in the lung outpatient treatment room at the Department of Pulmonologyand Respiratory Medicine. Method were uric acid levels examination before OAT administration, at week2 and 4. Paired t tests and spearman correlation test were used to analyze the association between sex, age,BMI and arthralgia with increased uric acid levels. The incidence of hyperuricemia and arthralgia wereperformed in percentage.Result: Seventeen subjects consisting of 9 (52.9%) males and 8 (47.1%) females who received oral antituberculosiscategory 1 mostly had normal BMI prior to treatment (9 patients, 52.9%). Uric acid levelsincreased significantly (p <0.005) at week 2 and 4 than before Oral Anti Tuberculosis (OAT) treatment.It was found significant relationship (p <0.005) between increased uric acid levels and arthralgia withhyperuricemia incidence of 82.35% and arthralgia incidence of 35.29%. There was no significant association(p <0.005) between increased uric acid levels with sex, age and BMI.Conclusion: It was found a high incidence of hyperuricemia (82.3%) in ETB and PZA treatment whilesymptomatic 35.29%.