Abstract

AbstractThe effect of pH, temperature, reactant concentration, and reaction time has been investigated for the synthesis of N‐benzhydryl‐N′‐acetamidopiperazyl‐6‐penicillanic acid and N‐benzyl‐N′‐acetamidopiperazyl‐6‐penicillanic acid from 6‐aminopenicillanic acid by the immobilized penicillin acylase from Escherichia coli. The synthesis of penicillins from carboxylic acids proceeds most rapidly at pH 5; with ethyl ester derivatives of carboxylic acids the pH optimum is higher (6–7). The most rapid synthesis of penicillins was obtained with ethyl ester derivatives of carboxylic acids. The optimum temperatures were 25–35°C.

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