Abstract
Background The aim was to investigate the potential factors related with overall survival of oligometastatic non-small-cell lung cancer (NSCLC) patients. Methods A literature search was conducted in databases including PubMed, Embase, and Cochrane library up to March 2017. The hazard radio (HR) as well as the corresponding 95% confidence interval (CI) were calculated, and all the statistics analysis was performed by the R 3.12. Heterogeneity was analyzed using I-squared and Cochran Q tests. Furthermore, sensitivity analysis was performed to evaluate the stability of results. Results In total, 6 articles were included in the meta-analysis. Nodal status was significantly correlated with the overall survival rate of NSCLC oligometastatic patients (HR: 1.69, 95% CI: 1.23–2.32, Z=3.20, P=0.001). No significant relationship was found between overall survival rate of NSCLC oligometastatic patients and the indicators including sex, stage, smoker, age, and histology. Notably, sensitivity analysis on data evaluating relationship between patients survival and the stage and histology showed that results were reversed after removing one of the studies. Conclusions Nodal status might be associated with the overall survival of oligometastatic NSCLC patients.
Highlights
Lung cancer is one of the leading causes of cancer-related deaths, and 80% among them are non-small-cell lung cancer (NSCLC) worldwide [1, 2]
Databases including PubMed, Embase, and Cochrane library were used for searching the English literature correlated with oligometastatic NSCLC. e search period was up to March 12, 2017. e keywords used for literature searching in Embase and Cochrane library mainly included (“Oligometastatic” or “oligometastasis”) AND (“NSCLC” or “nonsmall cell lung cancer”). e searching words in PubMed were as follows: (Oligometastatic[All Fields] OR oligometastasis[All Fields]) AND ((“carcinoma, nonsmall-cell lung”[MeSH Terms] OR (“carcinoma”[All Fields] AND “nonsmall-cell”[All Fields] AND “lung”[All Fields]) OR “nonsmall-cell lung carcinoma”[All Fields] OR “NSCLC”[All Fields]) OR “nonsmall cell lung cancer”[All Fields])
We found that nodal status was significantly related to the overall survival rate of NSCLC oligometastatic patients (HR: 1.69, 95% confidence interval (CI): 1.23–2.32, Z 3.20, P 0.001)
Summary
Lung cancer is one of the leading causes of cancer-related deaths, and 80% among them are non-small-cell lung cancer (NSCLC) worldwide [1, 2]. Due to limited diagnostic technology, most NSCLC patients are diagnosed with advanced cancer [1, 3], and almost half among them have distant metastases (such as brain, adrenal glands, bone, or liver) [3, 4]. Treatment technology develops continually, the survival of NSCLC patients is still poor due to the metastases [5, 6]. Oligometastasis is a notion that cancer patients develop 1–5 metastatic or recurrent lesions after treatment, which will affect the survival of patients [7]. It has been reported that local therapy such as radiotherapy and surgery can effectively improve the survival of patients with postoperative oligometastases [9]
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