Abstract
The effect of fabrication parameters (coating matrix, surface area) on the release patterns of 5-fluorouracil (5-FU) from ethylene-vinyl acetate (EVA) copolymer matrices was studied. Coating the matrix with an additional layer resulted in slower drug release and different release patterns. Decreasing the surface area available for release to one-half produced a proportionate decrease in the release rate. Studies were also carried out to determine the effect of the release environment (temperature, pH). The release rate increased with increase in temperature. On the other hand, the release characteristics of the copolymer matrix were unaffected by pH in the physiological range of pH values.
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