Abstract

The transfer of cholesteryl esters generated by lecithin-cholesterol acyltransferase to low- and very low-density lipoproteins is greatly modified under different physiologic and pathologic conditions. A major factor determining transfer rates is the level of unesterified chlesterol in the acceptor lipoproteins. Low cholesteryl ester transfer rates are chatacteristic of several groups at increased risk for coronary artery disease. This appears to reflect a systematic abnormality of free cholesterol metabolism and transport in these groups.

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