Factors affecting the proliferation of cardiomyocyte

Xixian Cao

doi:10.1051/e3sconf/202021803044

Abstract

Heart is one of the most significant organs in mammalian animals, it functions as a pump to make the blood flow from heart to the body tissue and turn back to heart, which can provide the oxygen and other nutrients with the body tissue and carry the waste from the body 86tissue. There is an increase found in the incidence of heart disease and the case fatality rate of heart disease all over the world, this is because the heart disease leads to the greater amounts of cardiomyocyte dead and the capability of cardiomyocyte proliferation is weaker. To treat the heart disease and recover the capability of cardiomyocyte proliferation, this article summaries three factors that can affect the capability of cardiomyocyte proliferation, which may help with the treatment of heart disease in the future.

Highlights

One of the most significant organs in mammals is heart[13]
There are three impacts which can affect the capability of cardiomyocyte proliferation
The nerve can improve the capability of cardiomyocyte proliferation

Summary

INTRODUCTION

One of the most significant organs in mammals is heart[13]. With the development of new technology, there are some investigations about the factors which have an influence on the proliferation of cardiomyocytes[4,5,6]. With the contracting and releasing of cardia muscle, the blood will flow from the heart to the body tissue and turn back to the heart, which is called double circulatory system. The function of that area will be recovered, which can prove that the cardiomyocytes are able to proliferate, and the new cardiomyocytes are made by the previous cardiomyocyte’s division[15]. Until 21 days after the experiment, the missing apex will be regenerated, and the function of the area will be almost complete recovered, which means the cardiomyocytes are able to proliferate and the new cardiomyocytes are made by the previous cardiomyocyte’s division. When there are plenty of cardiomyocytes have been died, the fibroblast will be filled with the missing area to form the cicatrix tissue, which can cause that the heart cannot contract and release in a normal way. We will investigate the different factors that can have the influence on the cardiomyocyte proliferation, which may be helpful to the treatment of heart disease

Nerves

MicroRNA

MiR-15

Extracellular matrix-periostin

DISCUSSION