Abstract
SUMMARY The concentration of oestrone sulphate in cows’ milk increases gradually during gestation. The pattern of increase is characterized by episodes of high values followed by periods of much lower values. Experiments carried out in goats during early pregnancy showed that the mammary extraction of [3H]oestrone sulphate under steady state conditions was 63·3 ± 8·1% (mean ± SEM). The specific radioactivity of oestrone sulphate in milk (dpm/ng) during these experiments was significantly lower than that in arterial or mammary venous plasma, whereas the concentration of endogenous oestrone sulphate in milk (ng/ml) was significantly greater than that in plasma indicating that the steroid was transferred from blood to milk against a concentration gradient. The results suggest that changes in the transport of oestrone sulphate across the mammary gland and in the local synthesis and metabolism of oestrone sulphate are factors that may influence the concentration of oestrone sulphate in milk.
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