Factors affecting long-term remission in patients with FSGS and NS.

Abstract

In FSGS with Nephrotic Syndrome (NS) 23 patients (61%) of 38 with functional outcome are in remission with very long follow up (from 60 to 331 months) after treatment with Steroids alone or in combination with Cyclophosphamide. It would be interesting to assess whether in 11 patients with follow up from 5 to 27.6 years some parameters are associated with less severe disease favouring very long term remission. Three parameters were considered [age<vs≥35 yrs, normal or high blood pressure (BP0 and BP1 ) baseline 24hP <vs≥ 6.5] to verify whether they assess lower disease severity favouring remission. Age≥ vs <35 yrs and BP1 va BP0 are characterized by very significant differences of age, baseline and last eGFR, TID score and AH score. The patients with baseline 24hP < vs ≥6.5) were significantly different only for proteinuric parameters (TUP/C, IgG/C, Alb/C, α1m/C). In all remission patients the last value of 24hP is not significantly different according to the considered parameters and is independent from the baseline values eGFR and TUP/C and duration of follow up