Abstract
Background: Liver regeneration for donors' graft in living donor liver transplantation (LDLT), is an example for liver regeneration in normal liver. In this study we spotted the light on liver regeneration in donors after LDLT, focusing on factors affecting it. Aim: To study the impact of different factors on liver regeneration in donors of living donor liver transplantation. Patients and methods: Between May 2013 and June 2019, 80 living donor liver transplants were performed in the liver transplant unit in EL-Maadi Armed Forces Hospital. All donors who provided liver grafts underwent volumetric spiral computed tomography (CT) scans preoperatively and postoperatively at time intervals of 1 week and 1, 3 and 6 months. Patients’ demographics, surgical data, and postoperative outcomes were correlated with liver regeneration data. 63 patients were males and 17 patients were females, with mean age 27.97yrs ± 5.3. They provided {72} right lobe (RL) grafts and 8 right posterior sector (RP) grafts. Results: No donor operation was aborted and surgical morbidity rate was {33.75%}, mostly biliary. All RP donors achieved complete liver regeneration after 3 months; only four RL donors achieved complete liver regeneration at 6 months. Conclusion: In this study, it was found that there were factors affecting regeneration like age, gender of the patient and graft size. But no effect was found with many factors as peri-operative liver function tests, steatosis, BMI, operative time, blood loss, blood transfusion and postoperative complications.
Highlights
Liver transplantation is one of the most effective ways of treatment for many patients with liver failure whatever the cause
Liver regeneration is critical in adult living donor liver transplantation (LDLT), and size considerations affect the selection of appropriate donor and recipient pairs [3]
Vascular outflow, graft to recipient weight ratios (GRWR), humoral factors, and graft quality have all been implicated in affecting liver regeneration
Summary
Liver transplantation is one of the most effective ways of treatment for many patients with liver failure whatever the cause It gives a strong impact on the patient outcome [1]. Liver regeneration is critical in adult living donor liver transplantation (LDLT), and size considerations affect the selection of appropriate donor and recipient pairs [3]. Liver regeneration for donors' graft in living donor liver transplantation (LDLT), is an example for liver regeneration in normal liver. In this study we spotted the light on liver regeneration in donors after LDLT, focusing on factors affecting it. Aim: To study the impact of different factors on liver regeneration in donors of living donor liver transplantation. Conclusion: In this study, it was found that there were factors affecting regeneration like age, gender of the patient and graft size. No effect was found with many factors as peri-operative liver function tests, steatosis, BMI, operative time, blood loss, blood transfusion and postoperative complications
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