Abstract
The interictal discharges of temporal lobe epilepsy (TLE) can be unilateral or bilateral. In addition, the ictal electroencephalogram (EEG) showed the discharges also tend to spread to the contralateral brain in TLE. The factors influencing unilateral and bilateral interictal discharges in TLE as well as ictal diffusion patterns in scalp EEG during onset of seizure were evaluated in the present study. This was a retrospective analysis of 129 patients with TLE. Cases were classified into unilateral and bilateral discharge groups based on interictal discharge patterns in the EEG. Differences between the two groups in age, gender, disease duration, seizure frequency, magnetic resonance imaging (MRI) findings, origin of TLE, antiepileptic drug (AED) administration, and ictal diffusion patterns during seizures were statistically analyzed. In addition, the differences in ictal diffusion patterns between left and right TLE were statistically analyzed. Statistically significant differences were not observed in gender, disease duration, seizure frequency, MRI findings, administration of AEDs, and ictal diffusion patterns between interictal unilateral and bilateral discharge groups but with statistically significant differences in age and side of origin of the TLE. In addition, whether the EEG-recorded diffusion pattern was confined to the same hemisphere or spread to both hemispheres was investigated and shown statistically significant differences between the left and right temporal lobes. Age and side of origin of TLE affects the TLE interictal discharge patterns. Older patients are more prone to bilateral discharges. Bilateral discharges are more common in right TLE, and the onset of EEG more likely to bilateral diffusion in right TLE.
Highlights
Epilepsy is a common neurological disease, and temporal lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy (DRE) [1], accounting for about 70% of cases of epilepsy [2]
This was a retrospective analysis of 129 patients with TLE who had undergone surgery; cases were classified into two groups of unilateral and bilateral discharge groups according to interictal discharge patterns in the EEG
Are the factors associated with the different discharge patterns of TLE, one might ask? Does duration of the disease and frequency of seizures lead to an increase in the discharge range? Is the pattern of ictal diffusion during a seizure related to the pattern of interictal discharge? Are there differences in ictal diffusion patterns between the left and right temporal lobes during seizures? based on the above issues, this study retrospectively analyzed 129 patients with TLE who had undergone surgery, along with analysis of preoperative interictal and ictal EEG data
Summary
Epilepsy is a common neurological disease, and temporal lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy (DRE) [1], accounting for about 70% of cases of epilepsy [2]. The location and range of interictal discharge, such as unilateral or bilateral interictal discharges, have important guiding significance for the determination and localization of epileptic foci, as well as the prognosis of surgery. It is very important to evaluate the degree of neurological impairment and to predict the prognosis of surgery through interictal and ictal discharge patterns of TLE. Are there differences in ictal diffusion patterns between the left and right temporal lobes during seizures? The differences in age, gender, duration of disease, seizures frequency, magnetic resonance imaging (MRI) performance, side of origin of TLE, antiepileptic drug (AED) administration, and ictal diffusion patterns between unilateral and bilateral discharge groups were statistically analyzed. The differences in ictal diffusion patterns between left and right TLE were statistically analyzed
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