Abstract
After thyroidectomy hypocalcaemia is the most significant complication for clinicians. In this study, we investigated the factors associated with development of hypocalcaemia after thyroidectomy. We investigated the patients prospectively for age, gender, preoperative diagnosis, hormonal status, operative time, operating surgeon, existence of parathyroid gland injury at the operation, parathyroid gland auto-transplantation, preoperative use of anti-thyroid drugs and amount of bleeding at the operation. After operation in 1 and 2 days, serum calcium and phosphor, and in the 1 day parathyroid hormone values were evaluated. The chi-square test was applied in the analysis of categorical variables. Logistic regression model was used to determine the risk of hypocalcaemia in the univariate analysis. Hypocalcaemia developed in 47 of 196 patients. Female gender, preoperative diagnosis of thyroid cancer and toxic nodular goitre, <3cm nodule size, parathyroid injury and auto-transplantation and low vitamin D levels were factors found to be associated with hypocalcaemia in the Logistic regression analysis. The factors associated with hypocalcaemia were defined to be "gender, preoperative diagnosis, parathyroid gland injury, nodule size and vitamin D deficiency", it is a multifactorial problem and it would not be proper to define a few etiological factors.
Highlights
Thyroidectomy performed for any cause is among the endocrine operations most commonly performed by surgeons [1]
Preoperative diagnosis of thyroid cancer and toxic nodular goitre,
The factors associated with hypocalcaemia were defined to be “gender, preoperative diagnosis, parathyroid gland injury, nodule size and vitamin D deficiency”, it is a multifactorial problem and it would not be proper to define a few etiological factors
Summary
Thyroidectomy performed for any cause is among the endocrine operations most commonly performed by surgeons [1]. The mortality after thyroid operations is nearly zero and these operations have no severe morbidity. The most common complications are superior and inferior nerve injury and hypocalcaemia. The rate of transient hypoparathyroidism following thyroid surgery is between 6.9 and 49%, while that of permanent hypoparathyroidism changes between 0.4% and 33%. Hypocalcaemia-related symptoms are observed 24 and 48 hours after the operation [2]. There are patients and clinical conditions under risk for hypocalcaemia
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