Factors Affecting Early Outcome in Sri Lankan Patients with Stroke (P06.234)

Abstract

Objective: To identify factors associated with early outcome after stroke in Sri Lankan patients. Background Majority of strokes and stroke-related deaths occur in the developing world, but little is known about the factors affecting stroke outcomes in developing countries. Design/Methods: We analyzed data from a prospective hospital-based Sri Lankan stroke registry (Ragama Stroke Registry). All patients with acute stroke admitted to the Colombo North Teaching Hospital (Ragama, Sri Lanka) over a one year period were studied. Factors associated with poor early outcome were identified by multivariate logistic regression. Poor early outcome was defined as severe disability at discharge [modified Barthel index (BI) of 0-12], severe handicap at discharge [modified Rankin score (mRS) of 3-5] or in-hospital death. Results: We studied 547 patients with stroke - 59.4% males; mean age (SD) 64(12.8) years. Of them, 460 patients (87.2%) had ischaemic strokes. 379 patients (69.3%) had severe disability at discharge [BI 0-12], and 435 (79.6%) had severe handicap at discharge [mRS 3-5]. There were 26 (4.7%) in-hospital deaths. Age ≥65 years, female sex and stroke severity (NIHSS score) were independent predictors of both disability [BI] and handicap [mRS] at discharge. Stroke severity was the only independent predictor of in-hospital mortality. High waist circumference (overweight/ obese) and a history of previous transient ischaemic attack were negatively associated with poor outcome. Type of stroke (ischaemic/ haemorrhagic), delay to hospital admission, previous stroke, systolic blood pressure on admission, prior antiplatelet therapy and presence of common stroke risk factors were not associated with functional outcome. Conclusions: Older age, female sex and stroke severity were the main predictors of poor early outcome after stroke in Sri Lankan patients with stroke. Supported by: University of Kelaniya, Sri Lanka and Japan International Cooperation Agency, Japan. Disclosure: Dr. Ranawaka has nothing to disclose. Dr. Alexander has nothing to disclose. Dr. Nawaratne has nothing to disclose. Dr. Liyanage has nothing to disclose. Dr. Kulatunga has nothing to disclose. Dr. Tissera has nothing to disclose. Dr. Cooray has nothing to disclose. Dr. Kasthuriratne has nothing to disclose. Dr. Wickramasinghe has nothing to disclose.