Factors affecting cardiovascular morbidity in young FMF patients. A comparative analysis in colchicine treated FMF patients with and without cardiovascular disease

Aj Roitman,O Kukuy,I Ben Zvi,A Livneh

doi:10.1186/1546-0096-13-s1-o47

Abstract

Background Familial Mediterranean fever (FMF) is the prototype of chronic auto-inflammatory diseases. During the FMF attacks there is an uncontrolled activation of an inflammatory cascade with a consequent release of many proinflammatory molecules, which subsides or slows down in between the attacks. Chronic inflammation has been found to be associated with higher incidence of atherosclerotic cardiovascular disease (CVD). Thus, being a chronic inflammatory disorder, it is speculated that FMF may be considered as an independent risk factor for CVDs. Most studies looking at the association between FMF and CVDs have focused on markers, suggesting increased atherosclerosis in FMF as compared to the general population. Yet, these studies yielded conflicting results. In the present study we analyze atherosclerosis morbidity in FMF, by comparing affected to unaffected FMF patients.

Highlights

Familial Mediterranean fever (FMF) is the prototype of chronic auto-inflammatory diseases
During the FMF attacks there is an uncontrolled activation of an inflammatory cascade with a consequent release of many proinflammatory molecules, which subsides or slows down in between the attacks
Chronic inflammation has been found to be associated with higher incidence of atherosclerotic cardiovascular disease (CVD)

Summary

Background

Familial Mediterranean fever (FMF) is the prototype of chronic auto-inflammatory diseases. During the FMF attacks there is an uncontrolled activation of an inflammatory cascade with a consequent release of many proinflammatory molecules, which subsides or slows down in between the attacks. Chronic inflammation has been found to be associated with higher incidence of atherosclerotic cardiovascular disease (CVD). Being a chronic inflammatory disorder, it is speculated that FMF may be considered as an independent risk factor for CVDs. Most studies looking at the association between FMF and CVDs have focused on markers, suggesting increased atherosclerosis in FMF as compared to the general population. Most studies looking at the association between FMF and CVDs have focused on markers, suggesting increased atherosclerosis in FMF as compared to the general population In the present study we analyze atherosclerosis morbidity in FMF, by comparing affected to unaffected FMF patients

Methods

Results

Conclusion