Abstract
BackgroundThe aim of the present research work was to fabricate a novel gastroretentive drug delivery system in the form of tablets using a combination of natural polymer and rice bran wax with an intention to control drug delivery and to enhance the gastric residence time of the model drug Famotidine in the gastrointestinal tract.ResultsThe results of the preliminary trial batches prepared by using the hot melt granulation technique resulting in six different formulations showed good physicochemical characteristics and tablets conformed to the Pharmacopoeial specifications. Gastroretentive tablets containing natural polymer showed prolonged drug release comparable to Methocel. The optimized formulation (C3) using 32 factorial design showed FLT 27 ± 2.47 s, SI 92.68 ± 1.36% and % CDR 98.89 ± 0.39% at 12 h. The stability studies indicated the stability of the formulation during storage.ConclusionsIt was concluded that the release profile fitted best to zero-order equation with non-Fickian diffusion mechanism of drug release which demonstrates swelling-controlled drug release mechanism. Thus, the formulated tablets have the potential for improved release and gastroretentive properties.Graphical
Highlights
The aim of the present research work was to fabricate a novel gastroretentive drug delivery system in the form of tablets using a combination of natural polymer and rice bran wax with an intention to control drug delivery and to enhance the gastric residence time of the model drug Famotidine in the gastrointestinal tract
The studies were performed at 40 ± 2 °C and 75 ± 5% relative humidity (RH) in the desiccators with saturated salt solution for up to 6 months [35]
3.1 Characterization of rice bran wax (RBW) The wax was characterized for various properties as per Pharmacopoeial guidelines (Table 2)
Summary
The aim of the present research work was to fabricate a novel gastroretentive drug delivery system in the form of tablets using a combination of natural polymer and rice bran wax with an intention to control drug delivery and to enhance the gastric residence time of the model drug Famotidine in the gastrointestinal tract. Controlled release drug delivery by oral route is widely used because of its easy administration, patient suitability and formulation changeability [2]. To achieve the suitable therapeutic activity, frequent dosing of drugs is necessary. Several attempts are being made to reduce dosing frequency of a drug delivery system providing therapeutically effective plasma drug concentration for a longer period of time in a controlled and reproducible manner [2, 3]. In the upper gastrointestinal tract (GIT), for achieving, local or systemic effects, gastroretentive drug delivery system (GRDDS) can be used to prolong the residence time of the drug and to target the sitespecific drug release. Prolonged gastric retention by these systems may improve bioavailability and dissolution for drugs that are less soluble in a high pH environment, provided that the drug is stable in gastric environment [4, 5]
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