Abstract

Drug-induced liver injury is an uncommon but potentially severe adverse reaction to drugs, which still nowadays challenges drug development and is a growing health problem. The bulk of reactions seen in clinical practice are caused by drugs in common use and otherwise safe for the vast majority of patients, which suggests that idiosyncratic hepatotoxicity has an important genetic basis. Hepatotoxicity can resemble any other hepatic disorder and continuous to be a challenge for clinicians since it is not associated with specific features. For diagnosing hepatotoxicity the suspicion is crucial and must be followed by a careful questioning on drug exposure as well as by a thorough exclusion of alternate causes. Causality assessment can be reinforced, using diagnostic scales. The role of liver biopsy is controversial. There is no specific therapy for hepatotoxicity asides the prompt withdrawal of the culprit drug and supportive measures.

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