Factor V Leiden mutation is not associated with ischemic stroke in Chinese young adults

Abstract

Objective To study the correlation between coagulation factor Ⅴ Leiden mutation and ischemic stroke in Chinese young adults. Methods From July 2016 to January 2018, 80 young patients with ischemic stroke (18-45 years) admitted to the Department of Neurology, the First Affiliated Hospital of Shantou University Medical College and 80 controls were enrolled prospectively. The demographic data, vascular risk factors were documented. Sanger sequencing was used to detect factor Ⅴ Leiden mutation. Results The 1 691 sites of factor Ⅴ genes in the case group and control group were all wild types. Multivariate logistic regression analysis suggested that hypertension (odds ratio [OR] 4.308, 95% confidence interval [CI] 3.321-5.067; P=0.001), hyperlipidemia (OR 2.734, 95% CI 2.214-3.378; P=0.005), and smoking (OR 5.293, 95% CI 3.003-6.180; P=0.010) were the independent risk factors for ischemic stroke in young adults, and high-density lipoprotein cholesterol (OR 0.611, 95% CI 0.457-0.709; P=0.027) was its independent protective factor. Conclusion Factor Ⅴ Leiden mutation is not associated with ischemic stroke in Chinese young adults. Hypertension, dyslipidemia and smoking are still the main risk factors for ischemic stroke in young adults. Key words: Stroke; Brain Ischemia; Factor Ⅴ; Point Mutation; Young Adults; Risk Factors