Factor V G1691A is associated with an increased risk of retinal vein occlusion: a meta-analysis.

Yuanyuan Zou,Xiangning Ji,Xi Zhang,Yuqing Liu,Jingyi Zhang

doi:10.18632/oncotarget.20636

Abstract

We performed a meta-analysis to investigate the association between the Factor V G1691A polymorphism and the risk of retinal vein occlusion (RVO). This analysis included 37 studies involving 2,510 cases and 3,466 controls. Factor V G1691A was associated with an increased risk of RVO in the allele, heterozygote, dominant, and carrier models (PA < 0.001, odds ratios >1), but not the homozygote or recessive models (PA > 0.05). Similar results were observed in a meta-analysis of central retinal vein occlusion (CRVO) and when comparing Caucasian subgroups to population-based controls. These data demonstrate that the G/A genotype of Factor V G1691A is associated with an increased risk of RVO/CRVO in a Caucasian population.

Highlights

RESULTSRetinal vein occlusion (RVO) is a multifactorial vascular disease characterized by retinal blood stasis, venous tortuous expansion, retinal hemorrhage, and edema that can cause loss of visual acuity loss or blindness [1].There are two main types of RVO, branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO), which are classified according to the sites of occlusion [2, 3]
Factor V G1691A was associated with an increased risk of RVO compared to controls in a Caucasian population under A vs. G (Table 3, PA < 0.001, OR = 1.75), GA vs. GG
G/A genotype of Factor V G1691A is associated with an increased risk of RVO ( CRVO) in Caucasians

Summary

RESULTS

Retinal vein occlusion (RVO) is a multifactorial vascular disease characterized by retinal blood stasis, venous tortuous expansion, retinal hemorrhage, and edema that can cause loss of visual acuity loss or blindness [1]. Factor V G1691A was associated with an increased risk of RVO compared to controls in a Caucasian population under A vs G (allele) (Table 3, PA < 0.001, OR = 1.75), GA vs GG Janssen et al performed a meta-analysis of 12 studies [12, 13, 17, 22, 27, 33, 34, 39, 41, 42, 46, 47] and found that the Factor V Leiden mutation (G/A+A/A) was associated with an increased risk of RVO [48]. GG model and data not shown) was indicative of stable statistical results

DISCUSSION

MATERIALS AND METHODS

CONFLICTS OF INTEREST