Abstract
Current guidelines lack consensus regarding the treatment of patients who may not benefit from dialysis; this lack of consensus may be associated with the substantial variation in dialysis use and outcomes across health care facilities. To assess the degree to which variation in dialysis use and mortality was associated with patient rather than facility characteristics and to distinguish which features identified the US Department of Veterans Affairs (VA) facilities with high rates of dialysis use. This cohort study analyzed data of veterans with stage 3 or 4 chronic kidney disease that progressed to kidney failure between January 1, 2011, and December 31, 2014. These patients received care from VA facilities across the US. Data sources included laboratory and administrative records from the VA, Medicare, and United States Renal Data System. Data analysis was conducted from August 1, 2019, to September 1, 2020. The primary exposure was the VA facility in which patients received most of their care before the onset of incident kidney failure defined as the first occurrence of either a sustained estimated glomerular filtration rate of less than 15 mL/min/1.73 m2 or the initiation of maintenance dialysis. The primary outcomes were dialysis use and mortality within 2 years of incident kidney failure. Median rate ratio was used to quantify facility-level variation, and variance partition coefficient was used to quantify the sources of unexplained variation. The cohort included 8695 older veterans with a mean (SD) age of 78.8 (7.5) years who were predominantly male (8573 [99%]) and White (6102 [70%]) individuals treated at 108 VA facilities. The observed frequency of dialysis use across facilities ranged from 25.0% to 81.4%, with a median (interquartile range [IQR]) rate of 51.7% (48.4%-60.0%). The observed frequency of mortality across facilities ranged from 27.2% to 60.0%, with a median (IQR) rate of 45.2% (41.2%-48.6%). The median rate ratio (adjusted for multiple patient and facility characteristics) was 1.40 for dialysis use and 1.08 for mortality. The unexplained variation in both outcomes mainly derived from patient characteristics rather than facility characteristics. No correlation was found between dialysis use and mortality at the facility level (correlation coefficient = 0.03). This study found sizable variation in dialysis use for older adults that was poorly correlated with facility-level mortality rates and was not accounted for by differences in measured patient and facility characteristics. These findings suggest opportunities to improve the degree to which dialysis use practices align with the values, goals, and preferences of older adults with kidney failure.
Highlights
For older adults approaching kidney failure, the decisions about whether and when to initiate maintenance dialysis are often complex given that the benefits of dialysis become less certain with increasing age and comorbidity burden.1-3 Guidelines, recommend the consideration of older individuals’ unique clinical histories and preferences when selecting treatment.4 Previous studies have observed variations in dialysis use across geographic regions and health care systems, suggesting that structural and practice-related factors affect their treatment.5-8 these comparisons are likely confounded by differences in the prevalence of chronic kidney disease (CKD) and other case-mix factors across settings.Evaluating variation in dialysis use and mortality at the facility level could provide insights into dialysis practices as well as inform policy and quality improvement efforts, which are often undertaken at the facility level
This study found sizable variation in dialysis use for older adults that was poorly correlated with facility-level mortality rates and was not accounted for by differences in measured patient and facility characteristics
These findings suggest opportunities to improve the degree to which dialysis use practices align with the values, goals, and preferences of older adults with kidney failure
Summary
For older adults approaching kidney failure, the decisions about whether and when to initiate maintenance dialysis are often complex given that the benefits of dialysis become less certain with increasing age and comorbidity burden. Guidelines, recommend the consideration of older individuals’ unique clinical histories and preferences when selecting treatment. Previous studies have observed variations in dialysis use across geographic regions and health care systems, suggesting that structural and practice-related factors affect their treatment. these comparisons are likely confounded by differences in the prevalence of chronic kidney disease (CKD) and other case-mix factors across settings.Evaluating variation in dialysis use and mortality at the facility level could provide insights into dialysis practices as well as inform policy and quality improvement efforts, which are often undertaken at the facility level. Previous studies have observed variations in dialysis use across geographic regions and health care systems, suggesting that structural and practice-related factors affect their treatment.. Previous studies have observed variations in dialysis use across geographic regions and health care systems, suggesting that structural and practice-related factors affect their treatment.5-8 These comparisons are likely confounded by differences in the prevalence of chronic kidney disease (CKD) and other case-mix factors across settings. Evaluating variation in dialysis use and mortality at the facility level could provide insights into dialysis practices as well as inform policy and quality improvement efforts, which are often undertaken at the facility level. Improved understanding of the degree and sources of variation within a health care system can help to identify best practices when treating older adults and to identify policy and practice levers that might be targeted for quality improvement initiatives
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