Abstract
Guinea pigs received intrahippocampal injections of procaine hydrochloride (P-HCl) or isotonic saline and were conditioned in a two-way avoidance situation. Animals receiving P-HCl acquired the learning criterion in significantly fewer trials than those receiving isotonic saline. Following acquisition, a shifting of drug conditions resulted in no change in the rate of avoidance responses but in altered rates of intertrial crossings. Animals shifted from P-HCl to isotonic saline decreased intertrial crossings, while those shifted from saline to P-HCl showed increased intertrial activity compared to animals that continued to receive the initial treatment.
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