Abstract
LSD-25 (0.05 or 0.1 mg/kg s.c.) facilitated the acquisition of discretetrial two-way avoidance by rats without causing marked changes in intertrial response frequency. Animals treated with 0.2 mg/kg of the drug before each session showed little or no facilitation, while higher doses, which are known to exert a depressant action in the same and other avoidance situations, were not tested in this acquisition study. These results and other published data on avoidance, on other simple tasks and on go-no go discriminations indicate that LSD-25 may have a fairly selective effect on drive modulating systems, i.e., cause a drive enhancement or disinhibition. The same data exclude gross changes in stimulus sensitivity as well as motor hyperactivity or a widespread impairment of response control (response disinhibition or perseveration).
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