Facilitated subcutaneous immunoglobulin use in pediatric patients with primary or secondary immunodeficiency diseases.

Abstract

Aim: While facilitated subcutaneous immunoglobulin (fSCIG) has been evaluated in pediatric patients with primary immunodeficiency diseases in clinical trials, real-world data are lacking. Materials & methods: This multicenter, retrospective, chart review study assessed fSCIG utilization in 30 patients less than 18years old, with primary or secondary immunodeficiency diseases. Medical records were reviewed at fSCIG initiation and at6months. Results: Most (90%) patients received their first fSCIG infusion at a medical facility; by 6months, all fSCIG infusions were administered at home by the patient/caregiver, the majority infusing every 3-4weeks into a single site. No serious adverse drug reactions occurred. Conclusion: This study supports the feasibility and tolerability of administering fSCIG at home to pediatric patients with immunodeficiencies. Clinical Trial Registration: DRKS00015436 (German Clinical Trials Register).