Abstract
A highly efficient synthesis based on inexpensive and readily available starting material towards the pharmacologically interesting class of substituted 2,3,4,7-tetrahydro-1 H-azepines via a ring-closing metathesis (RCM) approach employing Grubbs catalysts 1 and 2 is described. The influence of the substituents R 1 and R 2 on the outcome of the RCM reaction is discussed. The seemingly first example of an RCM approach towards seven-membered azacycles bearing a substituent at the alkene moiety utilizing Grubbs catalyst 1 is presented.
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