Facile Synthesis of Sequence‐Regulated Synthetic Polymers Using Orthogonal SuFEx and CuAAC Click Reactions

Abstract

AbstractThe orthogonal sulfur–fluoride exchange reaction (SuFEx) and copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) are employed to synthesize sequence‐regulated synthetic polymers. The high efficiency and broad tolerance of SuFEx and CuAAC to diverse chemical functionalities enable the one‐pot synthesis of polydispersed sequence‐controlled polymers by step‐growth copolymerization in high yield and sequence complexity. Furthermore, iterative SuFEx and CuAAC coupling reactions on a solid support, without the need of protecting groups, afford monodispersed sequence‐defined oligomers. The use of this orthogonal pair of click reactions provides new opportunities to facilely access sequence‐regulated synthetic polymers with a high degree of structural diversity.