Abstract
The synthesis of an amphiphilic, nonpeptidic scaffold that mimics the presentation of i, i+4, and i+7 residues of an α-helix is presented. The approach uses a pyridazine core, and minimizes the number of C-C bond forming reactions. The synthesis of this Urea-Pyridazine-Piperazine (UPP) scaffold is versatile and its synthesis makes it suitable for the preparation of small libraries of low-molecular-weight α-helix mimetics that can be targeted to specific protein/protein interactions.
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