Abstract
Inorganic structures with functionalized polymers play essential roles in diverse biological trends. Herein, thermal and CO2 dual-stimuli nanomaterials composed of mesoporous silica nanoparticles (MSN) anchored with two grafted copolymers: poly(3-methacryloxypropyltrimethoxysilane) "PMPS" & poly(N,N-dimethylaminoethyl methacrylate) "PDMAEMA" were synthesized via one-step reaction and characterized by BET as well as BJH methods to estimate pore sizes, pore volumes, and surface areas. The smart PDMAEMA acted as an active gatekeeper to adjust the loading or in vitro release processes of a fungicidal drug-loaded inside the mesopores by altering temperature or CO2 of the tested environment. Furthermore, treating the nanomaterials by CO2 for a few minutes was found to have a bactericidal effect with promising results as indicated by the disk diffusion technique. In general, the positive biological activity against selected strains of bacteria and fungi indicates that these particles may be helpful for engineering more efficient antifungal or antibacterial agents for pharmaceutical applications.
Highlights
Over the past two decades, smart polymeric materials have been exploited for versatile applications e.g. ion absorbance capacity,[1] wastewater treatment,[2] cargo delivery systems,[3] photodynamic or photothermal effects,[4] and enhancing the mechanical properties as well as the interfacial performance of specific fibers.[5,6] A famous example is mesoporous silica nanoparticles (MSN) which have been used widely as drug carriers in biomedical technologies, thanks to several merits e.g. biocompatibility, easiness of surface-modification, and controllable mesopore sizes.[7]
The critical pH for PDMAEMA chains needed to plug the pores of the prepared nanocarriers was measured to be pH 7.2 which is lower than 7.4 value
One can conclude that in case this system is used as a smart drug delivery nanocarrier, the release of any encapsulated-drug from MSN/P(MPS-co-dimethylaminoethyl methacrylate (DMAEMA)) can only be noticed after reaching the desired pathological organs, where the pH values are slightly acidic
Summary
Over the past two decades, smart polymeric materials have been exploited for versatile applications e.g. ion absorbance capacity,[1] wastewater treatment,[2] cargo delivery systems,[3] photodynamic or photothermal effects,[4] and enhancing the mechanical properties as well as the interfacial performance of specific fibers.[5,6] A famous example is MSN which have been used widely as drug carriers in biomedical technologies, thanks to several merits e.g. biocompatibility, easiness of surface-modification, and controllable mesopore sizes.[7]. 2020, 67, 462–468 polymer showed pretty good thermo-responsiveness, as it can form coil-to-globule states by changing temperatures degrees and showed a lower critical solution temperature (LCST) in aqueous solutions,[9] which is a similar character to the well-known thermosensitive poly(N-isopropylacrylamide) (PNIPAAm).[10,11] More interestingly, quaternization of terminal amino groups of PDMAEMA had promising antimicrobial activity against some bacterial strains.[12] Slov. 2020, 67, 462–468 polymer showed pretty good thermo-responsiveness, as it can form coil-to-globule states by changing temperatures degrees and showed a lower critical solution temperature (LCST) in aqueous solutions,[9] which is a similar character to the well-known thermosensitive poly(N-isopropylacrylamide) (PNIPAAm).[10,11] More interestingly, quaternization of terminal amino groups of PDMAEMA had promising antimicrobial activity against some bacterial strains.[12]
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