Abstract
Efficient synthesis of quinoxalines from gallic acid ethyl ester is reported for the first time in this study. The results show the production of three heterocyclic amines instead of the amides expected from aminolysis reactions. Ethyl 8-hydroxy-1,2,3,4-tetrahydroquinoxaline-6-carboxylate G-A1, ethyl 2,3,6,7-tetrahydro-1H,5H-pyrazino[1,2,3-de]quinoxaline-9-carboxylate G-A2, and ethyl 8-hydroxy-4-(2-hydroxyethyl)-1,2,3,4-tetrahydroquinoxaline-6-carboxylate G-A3 were obtained with 97, 92, and 95% yield, respectively, after 30min of reaction at 65°C and 400rpm using ethanol as a solvent.
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