Facile Synthesis of New Polyazamacrocycles by the Pd-Catalyzed Amination of 3,3'-Dibromobiphenyl

Abstract

Pd-Catalyzed amination of 3,3'-dibromobiphenyl using various polyamines and oxadiamines was studied. Target macrocycles were obtained in yields from moderate to good with a variety of polyamines and oxadiamines, cyclic oligomers were isolated in the majority of cases as by-products. Synthesis of the macrocycles containing two 3,3'-disubstituted biphenyls and two polyamine fragments (cyclodimers) was elaborated using intermediate di(bromobiphenyl)substituted polaymines or bis(polyamine)substituted biphenyls.