Facile synthesis of new organophosphorus compounds with -N-P(O)-N- linkage: Reaction between 2-pyrazoline and phosphorodichloridates/phosphonic dichloride

Abstract

Condensation of 3-benzoyl-4-phenyl-2-pyrazoline with various aryl phosphorodichloridates or trichloromethylphosphonic dichloride in the presence of a base resulted in the formation of arylbis (3-benzoyl-4,5-dihydro-4-phenyl-1H-pyrazol-1-yl)phosphinates and trichloromethyl-bis (3-benzoyl-4,5-dihydro-4-phenyl-1H-pyrazol-1-yl)phosphonate. The structures of the title compounds were confirmed by elemental analyses, IR, 1H, 13C, and 31P NMR spectra. The EI mass spectrum of one member of the family is discussed. These compounds were found to possess good antibacterial and antifungal activity. © 1997 John Wiley & Sons, Inc.