Abstract
In this study, manganese ferrite/graphene oxide (MnFe2O4/GO) nanocomposites as controlled targeted drug delivery were prepared by a facile sonochemical method. It was found that GO nanosheets were fully exfoliated and decorated with MnFe2O4 nanoparticles having diameters of 5–13nm. The field-dependent magnetization curve indicated superparamagnetic behavior of the obtained MnFe2O4/GO with saturation magnetization of 34.9emu/g at room temperature. The in vitro cytotoxicity testing exhibited negligible cytotoxicity of as-prepared MnFe2O4/GO even at the concentration as high as 150μg/mL. Doxorubicin hydrochloride (DOX) as an anti-tumor model drug was utilized to explore the application potential of MnFe2O4/GO for controlled drug delivery. The drug loading capacity of this nanocarrier was as high as 0.97mg/mg and the drug release behavior showed a sustained and pH-responsive way.
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