Facile Synthesis of Core-Shell Nanoparticles Silver/Cr2O3 Embedded with Ultrathin MoS2 Layers, Microstructure Analysis and Biocompatibility Enhancement by in vitro Evaluation of Antiproliferation and Antibacterial Activities

Abstract

Cost-effective methods were employed in this study to synthesize core-shell nanoparticles of silver/Cr2O3 (SM) embedded with ultrathin MoS2 layers (SM1) to increase the properties and biocompatibility of the nanomaterials. For structural and morphological investigation, powder XRD, TEM, SEM, EDAX and XPS were used. Magnetic behaviour of SM and SM1 nanoparticles investigated by VSM was shown to be ferromagnetic, and when MoS2 nanosheets were injected, their magnetism decreased. The zeta potential of SM1 was also analyzed. This nanomaterial was synthesized to test the biocompatibility effectiveness of anticancer and antibacterial compounds. In MCF-7 adenocarcinoma (breast cancer) and HepG-2 hepatocellular carcinoma (liver cancer) cell lines, SM1 was investigated for antiproliferation effectiveness. The MCF-7 and HepG-2 cell lines both showed strong cytotoxic potential. Antimicrobial activity was observed against Staphylococcus aureus and Escherichia coli. This study provides strong evidence to support the development of cytotoxicity and antimicrobial properties for significant biomedical compatibility by demonstrating a key to understanding the Ag/Cr2O3 nanoparticle embedded in 2D MoS2 nanosheets on forming a unique interaction as well as the strategy for achieving in vitro efficiency.