Facile synthesis of cellulose microfibers supported palladium nanospindles on graphene oxide for selective detection of dopamine in pharmaceutical and biological samples

Abstract

The cost-effective synthesis of novel functional nanomaterials has received significant attention in the physical and chemical sciences due to their improved surface area, high catalytic activity along with unique morphological features. This paper reports a facile and eco-friendly synthesis of spindle-like palladium nanostructures (PdSPs) on graphene oxide-cellulose microfiber (GO-CMF) composite for the first time. The GO-CMF/PdSPs composite was synthesized by an electrochemical method without the use of additional surfactants and capping agents. The synthesized materials were characterized and confirmed by using transmission electron microscopy, high-resolution scanning electron microscopy, X-ray diffraction spectroscopy, Raman spectroscopy and Fourier-transform infrared spectroscopy. As-synthesized GO-CMF/PdSPs composite modified electrode was used as a selective electrocatalyst for the oxidation of dopamine (DA). The electrochemical redox behaviors of DA were investigated using cyclic voltammetry (CV). The CV results revealed that the GO-CMF/PdSPs composite modified electrode has 10 folds enhanced oxidation current response to DA than GO, PdSPs and GO-CMF modified GCEs. Under optimized conditions, the GO-CMF/PdSPs composite sensor exhibits a linear response to DA in the concentration range from 0.3 to 196.3 μM with the lower detection limit of 23 nM. The nanocomposite electrode also shows promising features towards the reliable and selective detection of DA, which includes high stability, reproducibility and high selectivity towards the commonly interfering species such as ascorbic acid, uric acid, and dihydroxybenzene isomers. The sensor was successfully tested for the real-time detection of DA in the commercial DA injections and human serum samples.