Facile Synthesis of Amides through Transamidation with Iodine under Neat Conditions

Abstract

AbstractIodine and NH2OH.HCl mediated transamidation of unactivated amides with a variety of amines under thermal/microwave irradiations. The current strategy is effective for a wide variety of primary, secondary, and tertiary amides and allows formylation, acylation, and benzoylation of various amines. The primary advantages of the current protocol are simple, rapid, absence of metal catalyst, low‐cost starting material as a solvent, and low environmental impact during the synthesis process.