Facile synthesis of α,β-acetylenic ketones and 2,5-disubstituted furans: consecutive activation of triple and double bond with ZnBr 2 toward the synthesis of furan ring

Abstract

α,β -Acetylenic ketones were synthesized from the reaction of acid chlorides and acetylenic compounds in the presence of ZnBr 2 and DIEA in acetonitrile. From the acetylenic ketones having nearby methylene unit, 2,5-disubstituted furan derivatives could be synthesized under the same reaction conditions.