Facile Synthesis of 3-Aryl-5-(2-Oxopyrrolidin-1-yl)- and 5-(Pyridin-4-yl)-4,5-Dihydroisoxazoles via 1,3-Dipolar Cycloaddition under Mild Conditions

Abstract

A convenient and efficient synthetic approach for the synthesis of 5-substituted 3-aryl-4,5-dihydroisoxazoles is reported. In the presence of triethylamine, a series of hydroximoyl chlorides were transformed into nitrile oxides, followed by reaction with N-vinyl-2-pyrrolidinone (or 4-vinylpyridine) by a 1,3-dipolar cycloaddition to give novel 4,5-dihydroisoxazole derivatives.