Abstract
AbstractA practical and economical process for the synthesis of perfluoroalkylated indole compounds has been developed. The Michael addition of 2‐iodo‐ or 2‐bromoanilines to methyl perfluoroalk‐2‐ynoates affords N‐(o‐haloaryl)enamines, which subsequently undergo a copper‐catalyzed annulation reaction to give 2‐perfluoroalkyl‐substituted indoles in good to excellent yields. This method displays excellent functional group tolerance and is carried out in one pot under mild conditions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
