Abstract
[ 11C]Edrophonium and its analogues have been synthesized for evaluation as new potential positron emission tomography (PET) imaging agents for heart acetylcholinesterase. The tracers were prepared by N-[ 11C]methylation of precursors using [ 11C]methyl triflate and isolated by solid-phase extraction (SPE) purification procedure in 50–65% radiochemical yields.
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