Facile synthesis of α-tertiary alkyl/aryl amines via cu-catalyzed alkylation of indoles and anilines with tertiary alkyl bromides

Abstract

Methods of copper-catalyzed alkylation of indoles and anilines with tertiary alkyl bromides were reported. These protocols provided various N-tert-alkyl 3-substituted indoles and electron-deficient N-tert-alkyl anilines in moderate to good yields via CN coupling.