Facile selective detritylation of 5′‐primary alcohols of pyrimidine nucleosides using tetra‐n‐butylammonium peroxydisulfate

Abstract

Tetra-n-butylammonium peroxydisulfate has been found to be a good deprotecting reagent for removal of the trityl group: Treatment of 5′-O-dimethoxytrityl uridine or thymidine with tetra-n-butylammonium peroxydisulfate gave the corresponding dedimethoxytritylated nucleosides in excellent yields under neutral and mild conditions and without causing any side reactions such as cleavage of the glycosidic bond. © 1997 John Wiley & Sons, Inc. Heteroatom Chem 8: 435–438, 1997