Abstract
In order to enhance the dispersion ability of hydrophobic nanoparticles in water while maintainingtheir unique properties, we utilized poly(ethylene glycol) grafted hyperbranched poly(amido amine)(h-PAMAM-g-PEG) to modify three types of hydrophobic nanoparticle, CdSe, Au, andFe3O4, and transferred them into water to extend their applications in biology.Considering the large amounts of amino groups in hyperbranched poly(amido amine)(h-PAMAM) polymer, complexation interaction betweenh-PAMAM-g-PEG copolymer and nanoparticles was achieved and ligand exchange between thecopolymers and original small molecules ligands occurred. The transferred nanoparticlescould be easily dispersed in water with better stability, and their unique properties, such asfluorescence, surface plasmon resonance, and superparamagnetism, were well maintained inthe ligand exchange process. In addition, increasing the number of grafted PEGshowed a negative effect on the ligand exchange process. Due to the existence ofh-PAMAM-g-PEG ligands, the stabilized nanoparticles have improved stabilityin aqueous and ionic solutions. In the case of CdSe nanoparticles, theh-PAMAM-g-PEG layer leads to a lower cytotoxicity when compared with bare CdSeparticles, and they could be directly used in bioimaging.
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