Facile oxidative conversion of hydrazides of carboxylic acids to corresponding acids, esters and amides using copper compounds

Abstract

Oxidative conversion of hydrazides of carboxylic acids to acids, esters and amides using Cu salts was studied. Acids were obtained in high yields by using a catalytic amount of Cu(OAc) 2 at room temperature by bubbling oxygen. Hydrazides were converted to esters by the treatment with Cu(OR)Cl or Cu(OR) 2 formed in situ from CuCl 2 and sodium alkoxide. Amides were obtained in high yields by the oxidation of hydrazides with CuCl 2 in the presence of amines.