Abstract
The hollow nanospheres (NSs) composed of lanthanides have become a hot topic owing to their uncommon magnetic and optical properties arising from the 4f electrons. However, only a few novel methods have been developed for effectively integrating small calcium phosphate (CaP) nanoparticles and rare earth oxide drug carriers into an individual hollow mesoporous nanosphere. Herein, we report a facile, reproducible, room-temperature solution method to prepare multifunctional fluorescent hollow mesoporous Gd2O3:Eu/CaP (designated as HM-Gd2O3:Eu/CaP) NSs by using polyacrylic acid calcium (PAA-Ca) as a template. The excellent luminescent property and obvious T1-enhancement effect as well as the HM structure endow the HM-Gd2O3:Eu/CaP NSs with the capacity of simultaneous dual-modal fluorescence, magnetic resonance (MR) imaging and drug delivery. The nanocontainer-functionality of the HM-Gd2O3:Eu/CaP NSs is further validated upon filling with the anti-cancerogenic agent doxorubicin (drug-loading capacity is 749 μg mg−1). In addition, the HM-Gd2O3:Eu/CaP NSs display excellent pH-responsive and sustained drug release property. In vitro cell cytotoxicity tests verify the HM-Gd2O3:Eu/CaP NSs have good biocompatibility when the concentration ≤25 mg mL−1. Taken together, the results suggested that the HM-Gd2O3:Eu/CaP NSs can be applied as fluorescence and MR dual-modal imaging contrast agents and drug delivery vehicles.
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