Facile one-pot, three-component synthesis and antimicrobial screening of novel hexahydropyrimido[4,5-b]quinolinediones incorporating phenoxylacetamide core as novel hybrid molecules via Hantzsch reaction

Abstract

We have investigated in this article the introduction of the phenoxyacetamide moiety, which has different therapeutic activities, into the biologically important pyrimidoquinoline scaffolds to synthesize novel hybrid molecules with an effective therapeutic action for multifactorial illnesses. The Hantzsch process was used to synthesize novel hexahydropyrimido[4,5-b]quinolinediones with a phenoxylacetamide core at position-4 as unique hybrid compounds. The process is carried out in acetic acid via a three-component reaction involving the suitable aldehyde and one or two moles of both 6-aminothiouracil and 5,5-dimethyl-1,3-cyclohexanedione. Furthermore, all synthesized compounds were tested for antimicrobial activity, and the results were promising against a variety of multidrug-resistant microbial strains. These results were compared to the results of the in silico molecular docking study.