Abstract
In this study, a self-condensing vinyl copolymerization/redox (SCVP/Redox) system was constructed to prepare hyperbranched poly(methyl-6-O-methacryloyl-α-D-glucoside) by using Cu(III) as the initiator in aqueous solution, in which the –OH group in C-2, C-3 and C-4 position on pyranose rings could be initiated by Cu(III). The branched and linear units were clearly distinguished by nuclear magnetic resonance (1H NMR) to estimate the degree of branching (DB). When the ratio of Cu(III) to monomer fixed at 0.5:1, the DB value reached 0.32, which was higher than the product initiated by Ce(IV). Moreover, the inhibition activity of the products on amyloid fibrillation was investigated by using the hen egg-white lysozyme (HEWL) as a model based on the difference of the initiation sites. The results showed that the –OH groups in C-4 position might play an important role in this process.
Highlights
Glycopolymers, which are defined as the synthetic polymers bearing carbohydrates moieties as pendant or terminal groups, have drawn considerable attention in the fields of biomedicine and biomaterials, especially for drug-delivery systems, macromolecular drugs, biocatalysts and tissue engineering [1,2,3,4]
The 1 H Nuclear Magnetic Resonance (NMR) analyses showed that the oxygen radical (C–O) was generated by the redox reaction of Ce(IV) with –OH groups on the pyranose, while the pyranose rings were preserved [14]
The results showed that HPG-2 has similar inhibition activity to LPG-1 and the inhibition shows a positive relationship with the concentration
Summary
Glycopolymers, which are defined as the synthetic polymers bearing carbohydrates moieties as pendant or terminal groups, have drawn considerable attention in the fields of biomedicine and biomaterials, especially for drug-delivery systems, macromolecular drugs, biocatalysts and tissue engineering [1,2,3,4]. Many researchers have devoted themselves into the syntheses of glycopolymers with unique topological structures. A better alternative has been made accessible by developing hyperbranched glycopolymers via a one-pot reaction process. The hyperbranched glycopolymers possess similar physical and chemical properties. It is an acceptable approach to use the monomer containing carbohydrate unit for hyperbranched glycopolymers polymerization. Narain and coworkers synthesized galactose-based hyperbranched glycopolymers via the reversible addition-fragmentation chain transfer (RAFT)
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