Abstract
In the paper, the chitooligosaccharide (CHO) was surface-grafted on the medical segmented poly(ester-urethane) (SPU) film by a facile two-step procedure to improve the surface biocompatibility. By chemical treatment of SPU film with hexamethylene diisocyanate under mild reaction condition, free -NCO groups were first introduced on the surface with high grafting density, which were then coupled with -NH2 groups of CHO to immobilize CHO on the SPU surface (SPU-CHO). The CHO-covered surface was characterized by FT-IR and water contact angle test. Due to the hydrophilicity of CHO, the SPU-CHO possessed higher surface hydrophilicity and faster hydrolytic degradation rate than blank SPU. The almost overlapping stress-strain curves of SPU and SPU-CHO films demonstrated that the chemical treatments had little destruction on the intrinsic properties of the substrate. In addition, the significant inhibition of platelet adhesion and protein adsorption on CHO-covered surface endowed SPU-CHO an outstanding surface biocompatibility (especially blood compatibility). These results indicated that the CHO-grafted SPU was a promising candidate as blood-contacting biomaterial for biomedical applications.
Highlights
Segmented polyurethanes (SPUs) have been extensively used as biomaterials because of their superior tensile properties and adequate biocompatibility [1,2,3,4]
After segmented poly(ester-urethane) (SPU) film was treated with hexamethylene diisocyanate (HMDI), a new absorption peak at about 2269 cm−1 appeared (Figure 2b), which was attributed to the characteristic absorption of -NCO stretching vibration, strongly supporting that –NCO groups had been successfully introduced onto the film surface
By a facile two-step procedure, the natural biopolymer of CHO was surface-grafted on the SPU film (SPU-CHO)
Summary
Segmented polyurethanes (SPUs) have been extensively used as biomaterials because of their superior tensile properties and adequate biocompatibility [1,2,3,4]. They are used in the manufacturing of chronic implants, and have promise for bone implants and orthopedic due to the suitable processability, high flexibility, and bio-adhesion properties [5,6,7,8]. Natural biopolymers will not induce any toxicity or adverse response because of their excellent biocompatibility. They are biodegradable and can be metabolized completely after use [15,16]. The natural biopolymers are developed as biomaterials to replace or restore a function of the body while in contact with the body fluids
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